TEST ARTICLE: CYANOACRYLATE ADHESIVE MED-20

Acute Systemic Toxicity (USP): The saline, alcohol in saline, polyethylene glycol 400 and cottonseed oil extracts of the test article injected into mice did not produce a significantly greater systemic reaction than the blank extractant.

Intracutaneous Toxicity (USP): The saline, alcohol in saline, polyethylene glycol 400 and cottonseed oil extracts of the test article injected intracutaneously in rabbits did not produce a significantly greater tissue reaction than the blank extractant.

Implantation Test (USP): The macroscopic reaction of the test article implanted 3 days was not significant as compated to the USP negative control plastic.

The sample of test article extracted at a ratio of 120 sq. cm/20 ml and at a temperature of 50 degrees C for 72 hours met the requirements of a USP Class VI Plastic.